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Just because GPP is different it doesn’t make me different

The content presented on this website contains suggestions to help you manage your GPP.

Please discuss with your doctor what is best for you.

Generalized pustular psoriasis (GPP) is different from plaque psoriasis

Generalized pustular psoriasis symptoms (GPP symptoms) can be confused with plaque psoriasis, but they are two distinct conditions.

Both GPP and plaque psoriasis can appear as large areas of red, itchy, extremely dry, scaly, and cracked skin, but they are caused by different processes in the body. Additionally, genetic factors may play a role in each condition. This is why treatments that work for plaque psoriasis may not work the same way for GPP.

Generalized pustular psoriasis vs plaque psoriasis: geographical
The number of cases of GPP varies considerably across geographical regions, ranging from 1.76 to 124 per million people across France, Japan, Sweden and South Korea
Generalized pustular psoriasis vs plaque psoriasis: age
GPP may start around 40 years old, but can also occur at a younger age, although it’s uncommon
Generalized pustular psoriasis vs plaque psoriasis: gender
More women than men have GPP

Plaque psoriasis vs generalized pustular psoriasis (GPP)

Generalized pustular psoriasis vs plaque psoriasis: plaque psoriasis flare images

Plaque psoriasis

  • A common, life-long skin condition that affects 2–3% of the world’s population

  • The most common form of psoriasis, affecting nearly 8 out of 10 people with psoriasis

  • Psoriatic plaques are raised, inflamed, and scaly patches of skin that may be itchy and painful

  • Usually appears in people aged 16–22 years but can also appear in those at the ages of 57–60 years

  • Occurs equally in men and women

Generalized pustular psoriasis

Generalized pustular psoriasis (GPP)

  • A rare, life-long, systemic (whole body) condition

  • GPP flares appear suddenly as painful, sterile pustules (inflamed spots with pus) and may be accompanied by other general symptoms like fever, chills, joint pain and extreme tiredness

  • Most people experience ongoing symptoms, including skin scaling, crusting and redness

  • People with GPP have a greater degree of severe symptoms and greater levels of anxiety and depression compared with patients with plaque psoriasis*

  • Can occur in people who have plaque psoriasis

*According to a study of 60 people with GPP and 4,894 people with plaque psoriasis.

Potential causes of generalized pustular psoriasis (GPP)

Causes of generalized pustular psoriasis
Causes of generalized pustular psoriasis

What is the IL-36 pathway?

Causes of generalized pustular psoriasis: il-36 pathway
Causes of generalized pustular psoriasis: il-36 pathway

How is the IL-36 pathway linked to generalized pustular psoriasis (GPP)?

There are many different reasons why the IL-36 pathway can go awry in GPP, and in some cases, it is a combination of different factors. These can include:

  • Too many IL-36 agonists

  • IL-36 antagonists are not working

Causes of generalized pustular psoriasis: il-36 pathway linked to Generalized pustular psoriasis
Causes of generalized pustular psoriasis: il-36 pathway linked to Generalized pustular psoriasis